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KMID : 0605720030090020154
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Journal of the Korean Society of Biological Therapies in Psychiatry
2003 Volume.9 No. 2 p.154 ~ p.159
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The Angiotensin-Converting Enzyme Gene polymorphism with Bipolar Disorder
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김경나/Kim, Kyung-Na
김종우/정주호/이기철/정홍경/임성빈/Kim, Jong-Woo/Jung, Joo-Ho/Lee, Gi-Chul/Chung, Hong-Kyung/Yim, Sung-Vin
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Abstract
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Objectives : A possible participation of the Renin-Angiotensin System(RAS) in rectulating of the mood has been suggested by reports as follows ~ the angiotensin converting enzyme(ACE) is involved in the metabolism of the neuropeptide substance P implicated with novel strategies for the pharmacotherapy of depression and the use o` ACE inhibitors in hypertensive patients has been associated with euphoric or depressive states. The aim of the present study was to analyze the role of tree ACE gene I/D polymorphism for bipolar disorder.
Methods : We examined the frequency of a polymorphism characterized by the insertion or deletion of a 287-bp Alu repeat sequence in intron 16 of the angiotensin converting enzyme gene(located on chromosome 17823) in groups of patients with bipolar disorder(r~=82) compared to healthy control subjects(n=135). ACE genotype was determined by size-analysis of polymerase chain reaction products.
Results : The ACE I/D polymorphism did not show any difference in allelic frequencies and genotypic distributions between bipolar disorder patients and control subjects.
Conclusions : No significant association was found with bipolar disorder and the polymorphism of ACE gene. This findinca does not support that ACE I/D polymorphism is a significant risk factor for bipolar disorder .
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